Anopolis was in Roman and Venetian times larger and more prosperous.
The place had a harbor on the spot where now the village of Loutro is where the trading ships layers that were sent to various ports around the Mediterranean.
The remote location in the mountains made the town center was a revolutionary against foreign domination of Crete and Greece.
The rebellion led to Anopolis was destroyed by the Venetians in 1365 and in 1771 and 1867 by the Turks. In Anopolis is the church of Agios Georgios. Here cried Daskalogiannis in March 1770 a revolt against the Turks out, lifting. By a flag on the tower